Wegovy and Zepbound for Weight Loss

What are GLP-1 medications?
Wegovy and Zepbound are weekly injectable prescriptions that work by mimicking a natural hormone called glucagon-like peptide-1 (GLP-1) and in the case of Zepbound, dual action of GLP-1 and Glucose-dependent insulinotropic polypeptide (GIP).  These hormones helps regulate appetite and food intake by targeting specific areas in the brain.

To reduce gastrointestinal side effects, the dose is increased gradually each month. Maximum dosing is carefully titrated to help patients achieve safe, steady weight loss of about 1–2 pounds per week.

Who is eligible for GLP-1 agonists?

Wegovy is FDA-approved for adults who are:

• Obese (BMI ≥30)

• Overweight (BMI ≥27) with at least two weight-related health problem (such as high cholesterol, hypertension, fatty liver disease, or polycystic ovarian syndrome)

For best results, Wegovy and Zepbound should be combined with a reduced-calorie meal plan and regular physical activity.

Do not use GLP-1 medications if you:

• Have a personal or family history of medullary thyroid carcinoma (MTC)

• Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

• Have had a serious allergic reaction to semaglutide, tirzepatide, or any ingredients in Wegovy or Zepbound

• Have pancreatitis or consume alcohol heavily

• Are pregnant, planning pregnancy, or breastfeeding

Important considerations before starting GLP-1 therapy

Tell your provider if you have or have ever had:

• Pancreatic or kidney problems

• Type 2 diabetes, especially with a history of diabetic retinopathy

• Depression, suicidal thoughts, or other mental health concerns

• Pregnancy plans: You should stop using GLP-1 medications at least 2 months before trying to conceive

• Breastfeeding plans: It is not yet known if GLP-1 passes into breast milk

Medication interactions

Tell your provider about all medications and supplements you take, including:

• Prescription and over-the-counter medicines

• Vitamins and herbal products

Wegovy and Zepbound can affect—or be affected by—other medications, including insulin or sulfonylureas. Because these drugs slow stomach emptying, they may also change how quickly certain medications are absorbed.

Other options if you’re not a candidate

If GLP-1 therapy isn’t right for you, don’t lose hope. Thrive offers other safe, non-amphetamine weight management options. For example, Low Dose Naltrexone (LDN) therapy can be an effective alternative for some patients. (Read more on our blog.)

Next steps

To schedule your consultation for Wegovy, Zepbound, or another weight management plan, call 323-389-9191 or book online at www.ThriveWellnessLA.com.

Wegovy vs Zepbound: FAQ

What are Wegovy and Zepbound?
Both are weekly injectable medications that help with weight loss. They belong to a class of medicines called GLP-1 receptor agonists (Zepbound is also a dual GLP-1/GIP agonist).

How do they work?

• Wegovy (semaglutide): Mimics the hormone GLP-1, which reduces appetite, slows digestion, and helps control blood sugar.

• Zepbound (tirzepatide): Targets both GLP-1 and another hormone called GIP, which together enhance appetite control, improve blood sugar, and support more significant weight loss in many patients.

Who can use them?
Adults with:

• BMI ≥30 (obesity), or

• BMI ≥27 with weight-related health conditions like high cholesterol, high blood pressure, fatty liver disease, or PCOS.

How effective are they?

• Wegovy: Patients typically lose around 15% of body weight over time with diet and exercise.

• Zepbound: In studies, patients lost up to 20–22% of body weight, making it one of the most effective medications currently available.

What are the side effects?
Both can cause nausea, vomiting, diarrhea, or constipation which are usually mild and temporary as the dose increases. Rare but serious risks include pancreatitis and, in those with certain genetic risks, thyroid tumors.

Are there differences in insurance coverage?
Coverage varies by plan. Wegovy has been available longer, so more insurers may have established policies. Zepbound is newer, and coverage may still be expanding. However, the maker of Zepbound does have a direct pay discount program with marked discount over retail prices.  We can help you check with your insurance provider about coverage.

Which one is right for me?
Both are highly effective. Zepbound may offer greater weight loss for some patients, but Wegovy is also very effective and well-studied. The best choice depends on your medical history, insurance coverage, and personal goals. Your Thrive provider will help you decide.

What if I’m not a candidate for GLP-1 medications?
Don’t worry—other safe, non-amphetamine options are available, including alternatives like Low Dose Naltrexone (LDN) and personalized supplement plans.

The information provided on this website is for general knowledge and informational purposes only, and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment. The content on this website is not a substitute for professional medical advice, diagnosis, or treatment.